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Lean mass does include more than just skeletal muscle, but preserving muscle is essential, particularly in midlife and older adults, where age-related muscle loss (sarcopenia) is already occurring

Croner S, Larsson J, Schildt B & Symreng T (1985): Severe anorexia nervosa treated with total parenteral nutrition

Some clinical trials noted increased gallbladder events with GLP-1 medications

It helps regulate insulin release, reduce blood sugar levels, and prevent the liver from producing excess glucose

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In preclinical and clinical research, it has been investigated for its effects on glycemic control, body weight, and cardiometabolic risk factors in obesity and type 2 diabetes models