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Key finding: NNMT positioned as a master metabolic regulator at the intersection of NAD+ salvage, one-carbon metabolism, and epigenetic control

Joint discomfort is not listed as a recognised adverse effect in the BNF or licensed B12 product information, and most people taking B12 experience no musculoskeletal symptoms

So, now to consider what to do

Other types of intracytoplasmic inclusions such as Mallory bodies, lamellated, and crystalloid inclusions have been described in mice treated with different chemicals and in lysosomal storage diseases (Gebbia et al

when B12 level is low, two substrates of the enzymes will be built up total homocysteine (tHcy) and methylmalonic acid (MMA)

J Dev Physiol