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These genes encode proteins, enzymes, and other regulatory factors that are key components of mitochondrial biogenesis

Schwab et al., 1999

In detail, AR is imported into and localizes to mitochondria with the help of a genuine 36-amino-acid-long mitochondrial localization signal at the N terminus and impedes mtDNA content, TFAM expression, and the expression, assembly, stability, and activity of oxidative phosphorylation (OXPHOS) (90)

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Toufekoula et al., 2013)

Akkermansia muciniphila is a probiotic species which was described as "the most promising next-generation probiotic" in a medical review published in the Nutrients journal