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Other drugs in development Other multiagonists based on GLP-1 in combination with peptides such as GIP, GCG, PYY, secretin, and GLP-2as well as new triagonists and tetraagonists incorporating DACRA agonismare currently in the early stages of development1,59 (Table 2)

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Without continued dose escalation or therapeutic adjustment, appetite suppression fades while calorie consumption gradually increases, leading to plateau or reversal of weight loss

Understanding GLP-1 Medications: GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that work by mimicking the effects of a naturally occurring hormone in the body