semaglutide's weight loss effects traced to specific brain cells Semaglutide drives through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons The Unexplored Effects of Weight-Loss

Mir Ali, MD, board certified bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, who was not involved in the study, said: As far as I know, no definite mechanism to link GLP-1 medications and suicidal ideation [has been described]. He also said, There is disagreement because the incidence [of suicidal ideation] is so rare that it is difficult to accurately assess and try to delineate a possible reason for this. Separating existing psychological stressors from those possibly caused by GLP-1 is also difficult

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Suitability depends on BMI, health conditions, and long-term weight management goals