The FDA has warned about reports of adverse events from compounded semaglutide, and has found that some bootleg products contain ingredients such as semaglutide sodium and semaglutide acetate, which haven't been found to be safe or effective
Dihexa is a hard no
More recently, in the SURMOUNT-1 trial, the novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide showed a mean 15.0% reduction in weight with 91% of participants on the 15 mg once weekly dosage having at least 5% weight loss
However, it is important to note that there is insufficient data on safety or side effects in humans, and these peptides remain strictly for laboratory research purposes only
Cochrane handbook for systematic reviews of interventions, 2019: p
(2000) L-carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women, International Journal of Sport Nutrition and Exercise Metabolism, 10(2), pp