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Increases in the expression of various molecules that have been noted in reactive astrocytes across multiple contexts include GFAP, vimentin, nestin (probably labelling proliferating astrocytes), synemin plectin, -crystallin B chain, monoaminoxodase-B (MAO-B), heat shock factor binding protein 1, complement C3, lipocalin 2, C-X-C motif chemokine ligand 10, SerpinA3N, LCN2 and others, 20,95,96,97,98,99,100,101,102,103 but it important to note that no single molecular marker (including GFAP) is an absolute, required and sufficient, indicator of astrocyte reactivity, and no molecular markers have yet been identified that reliably distinguish amongst different reactive astrocyte phenotypes

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Ethics statement The studies involving humans were approved by the Institutional Ethics Committee of the First Affiliated Hospital of Xinxiang Medical University

This article covers the specific mechanisms that make the stack viable, the dose protocols researchers are exploring, and the monitoring parameters that distinguish safe co-administration from reckless polypharmacy

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Popova D, Forsblad A, Hashemian S, Jacobsson SOP (2016) Non-serotonergic neurotoxicity by MDMA (ecstasy) in neurons derived from mouse P19 embryonal carcinoma cells