However, other supplementations, such as vitamin E, C, and ferrous sulfate, did not offer a significant reduction in the depression score in this study due to many factors, such as the short trial duration, limited sample size in each group, low effective doses, and inadequate measurement at the start and end of the trial
Once depleted, NAPQI attacks liver cells and causes necrosis
-glucan: animal experiments have shown that oat -glucan can increase the abundance of Bifidobacterium and Lactobacillus in the intestines of rats (119, 120)
Even if the peptide does not directly bind to Cu, covering His residues (such as His259 and His263) will destroy the stable coordination of Cu and reduce its catalytic efficiency (Joompang et al., 2020)
Validation with longitudinal studies with a larger population size would further help to develop early screening tools for AD based on the same idea and is under process in our lab
Jahanban-Esfahlan A, Panahi-Azar V (2016) Interaction of glutathione with bovine serum albumin: Spectroscopy and molecular docking
