These classes were also associated with similar relative risk reductions in all-cause (12%-15%) and CV mortality (13%-15%)
Retatrutide is a triple receptor agonist , meaning it is designed to activate three distinct hormone receptors simultaneously: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
Additionally, GLP-1 has been shown to enhance the proliferation and differentiation of endothelial progenitor cells through upregulation of VEGF, potentially promoting angiogenesis that could contribute to retinal complications [101,102]
In the obesity group, there was a significant and clinically meaningful reduction in body weight of 4.74% at week 8, with weight continuously decreasing during the 8-week treatment period
& McMurray, J
Instead, they launched the most aggressive product imaginable, forced the FDA into a public response, and that response covers all GLP-1 APIs, including the injectables they were happily selling without scrutiny