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Extended Data Figure 6 Binding of GLP-1 and exendin-4 (9-39) to representative constructs

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This delayed transit promotes satiety and blood glucose control but can contribute to constipation in some patients

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Effectiveness Injectable tirzepatide, studied in the SURMOUNT clinical trial program involving thousands of participants, produced average weight loss of 15 to 22.5% of body weight over 72 weeks at the highest doses