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Ikemoto, S., Takahashi, M., Tsunoda, N., Maruyama, K., Itakura, H., & Ezaki, O
The review traced the developmental history of GLP-1 research from the identification of the proglucagon gene in 1982 through to the contemporary landscape of GLP-1-based therapeutics across obesity, cardiovascular disease, NAFLD, neurodegeneration, and cancer biology
In the TRIUMPH-1 Phase 3 trial, participants experienced up to 28.3% weight loss over 80 weeks, demonstrating its potential effectiveness against other medications like tirzepatide
The most common side effects were: Nausea Vomiting Diarrhea Constipation Fatigue Abdominal discomfort Early satiety Injection site reactions Increased heart rate in the first 24 weeks, but that returned to normal after 24 weeks
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