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Nakagawa, K., et al

Use it twice daily, in the morning and at night, for best results

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The STEP clinical trial program enrolled over 10,000 participants and demonstrated: - **Average 1517% body weight loss** in clinical trials - **Preferential fat mass reduction** analysis published in *Diabetes, Obesity and Metabolism* showed the majority of weight lost was fat tissue - **Sustained results** STEP 5 trial showed maintained fat loss over 2 years - **Once-weekly injection** convenient dosing for bodybuilders and athletes For detailed dosing protocols, see our [semaglutide dosing schedule guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)

Always consult with a healthcare provider before starting any new supplement

While some NHS areas may offer self-administration after appropriate training, this depends on local policy and is not routinely available everywhere