In an animal model, semaglutide demonstrated neuroprotective effects and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein involved in regulating the innate immune system and inflammatory responses
This is why stopping the medication during the early adjustment period (often the first month or two), when side effects are at their worst, often means missing the window in which the body would naturally adapt
TABLE 2 Comparative efficacy and safety profile of mainstream GLP-1 receptor agonists and dual agonists
[DOI] [PubMed] [Google Scholar] 112.Huang X, et al
If youre at a lower weight, but you have lower muscle mass, youre actually at higher risk for all-cause mortality
Acknowledgements We express our gratitude to the Vice-Chancellor for Research, Isfahan University of Medical Sciences for financial support through the scientific code 398979 and grant number 1989096