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L-Citrulline can be synthesized in the body as an intermediate in the conversion of orthinine to arginine in the urea cycle, it is also produced from arginine as a byproduct of the reaction catalyzed by the enzyme NO synthase

To validate the effectiveness of A-RDN, protein levels of calcitonin gene-related peptide (CGRP), which is the dominant neurotransmitter for afferent renal nerves [37, 38], and tyrosine hydroxylase (TH), a marker for efferent sympathetic fibers in the renal pelvis were quantified

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Sensory Sensitivities: Over- or under-reaction to sounds, textures, or lights

PRECAUTIONS:Avoid contact with eyes