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Given the limited evidence base, these recommendations should be regarded as cautious clinical guidance rather than firm directives

The December 2024 FDA advisory committee cited insufficient safety data for the injectable route as one reason for declining to approve compounding

However, bacteria have evolved multiple strategies to interfere with autophagic signals to avoid autophagy, and in some cases bacteria can even utilise autophagy to benefit their survival (Holla et al., 2014)

the first stage would be a narrow but focused transitional step to promptly address the most pressing concern that hospitals in the lowest-performing quartile of the Safety of Care measure group achieve the highest possible Overall Hospital Quality Star Rating while allowing hospitals and interested parties more time to prepare for the second stage, which will increase the impact of the Safety of Care measure group across all hospitals more broadly

avoid severe restriction that provokes GI distress