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La precocidad de la separacin de las curvas de aparicin de MACE entre los brazos de SEMA y placebo23 sugiere una potencial participacin directa de SEMA en los resultados del estudio SELECT, a travs de efectos promotores de angiognesis y reduccin de estrs oxidativo e inflamacin, en el contexto de acciones antiaterognicas derivadas de la activacin del GLP-1R que favorecen la funcin endotelial y la supervivencia celular7 (fig

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doi:10.1016/j.atherosclerosis.2020.01.010 14

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Novo is manufacturing the pill in the United States and has been building up supplies of the pill "for some time" to ensure that it has "ample supply", David Moore, Novo's executive vice president of US operations said

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