NICE guidance (TA875) recommends it only within specialist weight management services for adults with: A BMI of 35 kg/m or more (or 32.5 kg/m or more for people of South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean family background), and At least one weight-related comorbidity
Given their antiinflammatory properties, there has been some speculation that GLP-1 medicines could impair host immune defenses, but current clinical evidence does not indicate an increased risk of infections or obesity-related cancer (94)
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PLoS ONE 2016, 11, e0149549
Cutting funding without considering these downstream cost implications risks shifting expenses rather than eliminating them, potentially creating larger budget impacts over time
In this context, a short-term positive effect of fenfluramine, another serotonin releasing agent, in patients with PWS has been previously reported