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SNAC functions through a multifaceted mechanism: it buffers the local gastric pH, thereby protecting semaglutide from acidic degradation and proteolytic enzymes, and enhances drug solubility and monomerization

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Its half-life is short (7 minutes) because it is rapidly cleaved by dipeptidyl peptidase-IV (DPP-IV) after residues 2-3

Mitochondrial dysfunction in schizophrenia: Pathways, mechanisms and implications