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Compounded GLP-1 medications have become popular due to low costs and easy accessibility

For most patients, prescription GLP-1 medications are the safer and more reliable option due to standardization and clinical testing

doi: 10.1210/endo.133.1.8319572 47 DamholtABBuchanAMKofodH

These drugs are meant to be taken long-term

It is an investigational medicinal product (IMP) and has not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)

the reduced lateral diffusion of GLP-1R V229A could therefore be due to the mutant receptor existing as a subpopulation of pre-clustered, higher order oligomeric assemblies in absence of agonist stimulation, predicted to cause a decrease in the movement of these clusters and potentially hinder cholesterol binding