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This page summarises the published preclinical and limited human pilot data, the proposed mechanisms of action, the safety profile reported in those studies, and the regulatory framing in the United Kingdom

In fact, many countries have a higher recommended intake for B12 than we have in the U.S

After that, a once per month dose is needed to maintain proper B12 levels

Notably, no lethal dose could be determined in animals (no LD50 established)