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Semaglutide vs tirzepatide, and the honest 2026 picture on compounding Tirzepatide activates two gut-hormone receptors instead of one and showed larger average weight loss in trial data, but semaglutide has a longer track record and broader insurance familiarity and is the right choice for many patients

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The study assessed weight loss in two groups of Virta members with type 2 diabetes: those for whom (a) GLP-1s were fully deprescribed and (b) GLP-1s were continued

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