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Cooke, Paul S., et al
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For the experimental group, participants had to be on a maintenance dose (at least 4 weeks, Supplemental Table 1) of a GLP-1RA medication for weight loss
Sikiric et al., 2017
From my experience, once patients see how easy it is, even if theyre initially nervous, they often feel confident enough to continue the medication long term
The New England Journal of Medicine commentary accompanying SURPASS-2 stated: "The dual incretin approach appears to exploit receptor crosstalk in ways that amplify downstream insulin secretion beyond what GLP-1 receptor agonism alone can achieve at comparable tolerability." [30] SURPASS-1: Monotherapy Benchmark SURPASS-1 (N=478) established monotherapy efficacy, with tirzepatide 15 mg reducing A1C by 2.07 percentage points and body weight by 9.5 kg at 40 weeks versus placebo [31]
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