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Growth hormone secretion among adult patients with Prader-Willi syndrome due to different genetic subtypes

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To address this gap, we investigated how endothelial-specific IGF- 1R signaling regulates skeletal muscle vascular function using a mouse model of endothelial IGF- 1R knockdown ( VE-Cadherin-Cre ERT2 /Igf1r f/f ) [22, 31, 44]