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While these macrophages are known to secrete TGF-, which promotes collagen expression and fibrosis, it remains to be established whether this pathway is active in lipedema pathogenesis (Thomas and Apovian, 2017)

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Activation of the Hippo/TAZ pathway is required for menstrual stem cells to suppress myofibroblast and inhibit transforming growth factor signaling in human endometrial stromal cells

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CLA (conjugated linoleic acid) is a fatty acid that naturally occurs in meat and dairy from ruminants

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