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Conflict of interest Flynn McGuire, Riley Martinez, Annika Lenz, Lee Skinner, and Dan Cushman declare that they have no conflict of interest
MS, APS, LM, AM, CB and DS were responsible for the data collection and analysis
PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility
GLP-1 medications like Ozempic and Wegovy are changing how people manage weight
measured 705 nanomoles of copper through microneedle-treated skin in 9 hours, which is approximately 45 micrograms 3