The REDEFINE 2 trial examined the combination in adults with type 2 diabetes, where weight loss is typically harder to achieve due to insulin resistance and medication effects
Reported molecular endpoints include VEGFR2 expression and internalisation, FAK and paxillin phosphorylation, growth hormone receptor expression in tendon fibroblasts, and Egr-1 pathway activity
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Record side effects and adjust the dose rather than stopping abruptly
Another study developed pH/ROS dual-responsive metformin-released-enhanced self-healing bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic acid and L-arginine co-grafted chitosan hydrogel to enhance wound healing through decreased inflammation and enhanced angiogenesis in a rat type II diabetic model
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