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According to NICE guidance, GLP-1 receptor agonists are recommended for specific patient groups with type 2 diabetes (NG28) and, in some formulations like Wegovy (semaglutide 2.4mg) and Saxenda (liraglutide 3mg), for weight management in adults with obesity or overweight with weight-related comorbidities

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Additionally, TGR5 exerts anti-inflammatory effects by inhibiting NF-B-mediated pro-inflammatory cytokine production and modulating NLRP3 inflammasome activation (76)