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GLP-1 medications are not recommended for people with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

People who take both a GLP-1 medication for weight loss and a sulfonylurea drug to treat diabetes may experience dangerously low blood sugar levels

Whilst many patients experience mild, transient episodes that resolve with dietary modification, a subset develops severe, recurrent hypoglycaemia that significantly impacts quality of life and may require medical intervention

It also fluctuates widely with your caloric intake, which we see affected by GLPs

Surgical Approaches to Volume Restoration Surgical interventions often become necessary when volume loss is accompanied by tissue descent and skin laxity that cannot be adequately addressed with injectables or nonsurgical techniques alone, said Grob

doi: 10.1001/jama.2018.13022