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The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide
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This designation allows the use of this chemical strictly for in-vitro laboratory testing and experimentation
Various sources were referred to in the secondary research process to identify and collect information for this study
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