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The double-blind clinical trial of 1961 adults with overweight or obesity without diabetes found that the average weight loss after 68 weeks was about 15 percent of body weight for those given semaglutide versus only about 2.5 percent for those taking the placebo

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These findings reveal the high degree of molecular heterogeneity underlying genetic obesity and indicate that its clinical manifestations can range from relatively isolated severe metabolic disturbances to complex syndromes accompanied by significant neurodevelopmental defects

10.1016/S2213-2600(23)00142-X 69