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The non-inferiority (NI) in increased CV risk between SEM and placebo was concluded if the upper bound of the two-sided 95% CI of the for SEM versus placebo was less than 1.8 for time to first occurrence of MACE, in accordance with the FDA guidance on the development of a new antidiabetic therapy to treat T2DM

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The role of lifestyle modification with second-generation anti-obesity medications: comparisons, questions, and clinical opportunities

Nat Commun 16 , 9363 (2025)

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