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Am Fam Phys 88:589595 Caputo F, Bernardi M (2010) Medications acting on the GABA system in the treatment of alcoholic patients

In men, therapies such as testosterone replacement may impact fertility by suppressing reproductive hormones and raising SHBG while lowering free testosterone levels

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Since GLP-1 drugs also have an effect on inflammation and the immune system, theoretically combining them with biologics could create a heightened risk of infection or immune-related issues

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Instead of discouraging continued use, these side effects reinforced the belief that the drug was effective