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In cases of Peutz-Jeghers syndrome (PJS), which is characterized by intestinal hamartomatous polyps and mucocutaneous melanocytic macules, management includes surveillance for associated malignancies rather than specific treatment for the pigmentation itself

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The synthesis of GSH depends on the cystine/glutamate antiporter system XC (SLC7A11), and the regulation of this system can enhance or weaken cells

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The following section discusses another important stress factor: mechanical stress and lodging