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Immunomodulatory microneedle patch for enhanced ferroptosis and immunogenic cell death in postoperative tumor therapy

One method involves increasing the dose, but this may be restricted by gastrointestinal side effects

Furthermore, organic anion transporter (OAT)1 has been demonstrated to be involved in the transport of UA in a dose- and time-dependent manner, and it has been suggested to serve a role in the first step of urate secretion, specifically, the uptake of urate from the peritubular space into renal tubular cells (40,41)

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Furthermore, clinical trials involving the Shoemaker Protocol utilized repetitive "re-exposure" studies