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doi: 10.3389/fphar.2020.580289 Received 05 July 2020 Accepted 22 October 2020 Published 30 November 2020 Volume 11 - 2020 Edited by Damiana Scuteri, University of Calabria, Italy Reviewed by Robert L
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Weight Management: Semaglutide has been shown to be effective in promoting weight loss and improving body composition by reducing calorie intake, increasing energy expenditure, and targeting visceral fat accumulation
Beyond FSP1 there are therapeutic opportunities across the CoQ 10 oxidoreductase network While FSP1 currently has the strongest targetability signal, other CoQ 10 oxidoreductases may be therapeutically leveraged in defined genetic, metabolic or tissue contexts: (1) DHODH axis (mitochondrial defense in select contexts): DHODH connects pyrimidine synthesis to mitochondrial CoQ reduction, and in some settings, DHODH inhibition has been proposed to heighten ferroptosis sensitivity, especially in GPX4-low states
