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Proteolytic Resistance: Protecting the peptide backbone from rapid enzymatic degradation by local endopeptidases

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Research domains include cellular senescence, tissue aging, and experimental longevity models

In a research context comparing tirzepatide to semaglutide on a purely GLP-1-mediated endpoint, that affinity gap matters: at equivalent molar doses, tirzepatide engages GLP-1R less than semaglutide does

doi: 10.1210/js.2019-00078 52 Abraham GnanadassSDivakar PrabhuYValsala GopalakrishnanA

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