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The OA mice were randomly divided into three treatment groups ( n = 6 per group): (1) PBS, (2) CuS NPs, and (3) B2M-CuS NPs

Studies were eligible to be included if atleast one of the treatment arms were either GLP-1 RAs or SGLT2is or their combinations

MOTS-c has the most direct disc-specific evidence, with rat studies showing preserved disc height and reduced degeneration scores

Samples were placed in the autosampler and kept at 4 C until the injection (20 l)

GLP-1 medications mimic this hormone to slow gastric emptying, reduce hunger, stabilize blood glucose, and increase satiety, helping patients maintain a calorie deficit