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Activation of nuclear factor-B (NF-B) induces transcription of target genes that primarily encode survival proteins (e.g., cellular FLICE-like inhibitory protein and inhibitor of apoptosis proteins) via formation of the complex I signalosome after binding to TNF receptor-1

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Multiple preclinical and clinical studies showed that epigenetic mechanisms are involved in the pathophysiology and treatment of stress-related depressive and cognitive disorders

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doi:10.1016/j.fertnstert.2023.01.022

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