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This is particularly important during cold weather or in dry environments, where the respiratory tract can become irritated and inflamed

Apart from inclusion and exclusion criteria, the discrepancy between datasets can be alleviated through the application of appropriate validation criteria for the relevance, reliability, and quality of the RWD 14 and by particularly focusing on confounders related to exposure and outcome 15

J Biol Chem 229:189197 Rotruck JT, Pope AL, Ganther HE et al (1973) Selenium: biochemical role as a component of glutathione peroxidase

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British chemist Henry Fenton discovered that the mixture of hydrogen peroxide and ferric ions has strong oxidative properties, with the main oxidative component being the hydroxyl radical (OH)