Data Availability Statement Data are available on request
Patients pairing GLP-1 therapy with HRT may experience: Greater total weight and fat loss compared to GLP-1 therapy alone Improved body composition and muscle tone Enhanced energy and daily performance More consistent, lasting results Clinical insights suggest that addressing hormonal imbalances alongside GLP-1 therapy may lead to up to 30% greater weight loss in appropriate candidates
Specifically, neuropeptide Y/agouti-related protein (NPY/AgRP) neurons control appetite by the orexigenic effect47), and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons are sensitive to peripheral hormones such as insulin and leptin by anorexigenic effects48)
The advisory emphasises that "decisions about how quickly or slowly to titrate therapy should be guided by an individual's needs." This requires precise, ongoing body composition data, not just weight
If you notice increased hunger at the end of the week, it is important to discuss this with your provider rather than increasing your injection frequency
Ocular surface immune cell diversity in dry eye disease
