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The primary objective of this research is to elucidate the mechanisms underlying the glucose-lowering and metabolic effects of semaglutide

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We nevertheless observed, by RICCS analysis, a tendency for reduced co-diffusion of Laurdan with GLP-1R V229A under vehicle conditions, an effect normally only present in stimulated conditions for WT receptor, with no further change after agonist stimulation observed for the V229A mutant, suggesting a different pattern of interaction of V229A versus WT GLP-1R with plasma membrane lipids