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Treatment with a GLP-1 RA led to a significant improvement in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CCS) compared with placebo (7.8 and 7.3 points, respectively) and in the 6-minute walk distance (20.3 m and 14.3 m, respectively) at the 52-week follow-up

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Additionally, berberine shows a greater reduction in waist circumference and waist-to-hip ratio compared to the metformin group. If you have PMOS, you have a higher risk of heart disease

Pregnancy and breastfeeding: Berberine is not recommended during pregnancy or breastfeeding