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The STEP 2 trial, published in The Lancet , focused on individuals with both obesity and type 2 diabetes

In fact, the available evidence supports a functional hyperinsulinism driven at least in part by high levels of glucose and incretin after meals rather than increased islet cell mass, thereby questioning the concept of nesidioblastosis 151,152

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SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications