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FASEB J 7 : 13441353

Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats

As a widely used antihypertensive drug, losartan enhances vascular perfusion, thereby enhancing drug delivery and intratumoral invasion of immune effector cells and, on the other hand, enhances chemotherapy sensitivity by inhibiting IGF-1 signaling to reshape ovarian cancer and the microenvironment (140)

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Unmanaged interactions may disrupt drug metabolism pathways, heightening toxicity or reducing therapeutic effectiveness-particularly in vulnerable populations (49, 94)