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In this simulation also we chose \(\mu =-2.8\) as the initial value
Elderly patients might have decreased clearance and be more prone to nausea or dehydration, so timing should consider frailty and functional status
Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D et al
Further Reading References: (1) Laferrre B, Abraham C, Russell CD, Bowers CY