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Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer

Lipopolysaccharide (LPS), an endotoxin shed by gram-negative bacteria, enters circulation and triggers systemic inflammatory cytokines that can cross the blood-brain barrier and activate microglia, the brains resident immune cells

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(d) elevated systolic blood pressure equal to or greater than 130 or elevated diastolic blood pressure equal to or greater than 85 or on drug therapy for hypertension, (e) elevated fasting glucose level equal to or greater than 100 mg/dL or on drug therapy for hyperglycemia/diabetes)

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As demonstrated in the study by Iijima et al., the use of an integrated approach combining meta-analysis and multi-omics data has elucidated the pathogenic mechanisms of age-related KOA in mice [191]