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One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity

It was double-blinded, randomized, and placebo-controlled [9]

doi: 10.1155/2013/621453

When to Seek Professional Guidance Consult a healthcare professional if: You suspect B12 deficiency You experience neuropathy symptoms in the feet You want to explore B12 nerve-targeted injection programmes B12 injections in the foot and ankle are most effective when part of a comprehensive neuropathy care plan , including nutrition, lifestyle, and medical support

Indeed, controversy still surrounds the advantages and effectiveness of the oral route

It rejected emideltide, a peptide for sleep disorders, but the FDA retains final say