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Many systemic inflammatory conditions have gastrointestinal components that benefit from this approach

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5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage

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To test this idea, we synthesized ZZ2 ( 5 ), which has an additional chloro substituent adjacent to the existing sulfonyl fluoride moiety of ZZ1 (Fig

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