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Tirzepatide for Perimenopause Weight Gain: Mechanisms Perimenopause introduces a metabolic penalty: estrogen decline reduces resting metabolic rate by 2-8%, while progesterone loss increases hunger signaling and preference for calorie-dense foods

Lanz, R., Kuhnert, P., and Boerlin, P., Vet

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"This survey provides a helpful pulse on the HR community's need for a game plan around GLP-1 medications

It is widely distributed throughout the central and peripheral nervous systems, as well as immune and endocrine tissues

Some individuals lose less than 5% of their body weight, whereas others lose more than 20%