Further to this, recent studies suggest that Akkermansia can also directly stimulate GLP-1 secretion
Data from the longest clinical trial of Wegovy showed that 17% of people using the drug decided to stop participating in the trial because of side effects
10.1016/j.bbih.2021.100264 481 WuH.ChiouJ
But here is where the narrative starts to fall apart when you look more carefully
Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)
If blood sugar management is part of the goal, clinicians may look at your day-to-day glucose patterns for early insight, while tracking longer-term markers like A1C changes and weight trends over time